| Saturday 17th December 1977 | |||
| AP Leamington | 0-0 | Southend United | |
| Blyth Spartans | 1-0 | Chesterfield | |
| Carlisle United | 3-1 | Chester City | |
| Crewe Alexandra | 0-0 | Scarborough | |
| Gillingham | 1-1 | Peterborough United | |
| Grimsby Town | 2-0 | Barnsley | |
| Hartlepool United | 4-2 | Runcorn Halton | |
| Minehead | 0-3 | Exeter City | |
| Northampton Town | 0-2 | Enfield | |
| Nuneaton Borough | 1-2 | Tilbury | |
| Plymouth Argyle | 1-0 | Cambridge United | |
| Portsmouth | 2-2 | Swansea City | |
| Preston North End | 0-2 | Wrexham | |
| Rotherham United | 6-0 | Spennymoor United | |
| Shrewsbury Town | 1-1 | Stockport County | |
| Swindon Town | 2-1 | Brentford | |
| Walsall | 1-1 | Port Vale | |
| Watford | 2-0 | Colchester United | |
| Wealdstone | 2-1 | Reading | |
| Wigan Athletic | 1-0 | Sheffield Wednesday | |
| Monday 19th December 1977 | |||
| Replay | |||
| Port Vale | 1-3 | Walsall | |
| Southend United | 4-0 | AP Leamington | |
| Stockport County | 1-2 | Shrewsbury Town | |
| Tuesday 20th December 1977 | |||
| Replay | |||
| Peterborough United | 2-0 | Gillingham | |
| Swansea City | 2-1 | Portsmouth | |
| Wednesday 21st December 1977 | |||
| Replay | |||
| Scarborough | 2-0 | Crewe Alexandra | |
