| Friday 6th January 1978 | |||
| Leyton Orient | 1-1 | Norwich City | |
| Saturday 7th January 1978 | |||
| Birmingham City | 4-0 | Wigan Athletic | |
| Blackburn Rovers | 2-1 | Shrewsbury Town | |
| Blyth Spartans | 1-0 | Enfield | |
| Brighton and Hove A | 3-0 | Scarborough | |
| Bristol City | 4-4 | Wrexham | |
| Burnley | 1-0 | Fulham | |
| Cardiff City | 0-2 | Ipswich Town | |
| Carlisle United | 1-1 | Manchester United | |
| Charlton Athletic | 0-2 | Notts County | |
| Chelsea | 4-2 | Liverpool | |
| Derby County | 3-2 | Southend United | |
| Everton | 4-1 | Aston Villa | |
| Exeter City | 2-2 | Wolverhampton Wndrs | |
| Grimsby Town | 0-0 | Southampton | |
| Hartlepool United | 2-1 | Crystal Palace | |
| Hull City | 0-1 | Leicester City | |
| Leeds United | 1-2 | Manchester City | |
| Luton Town | 1-1 | Oldham Athletic | |
| Mansfield Town | 1-0 | Plymouth Argyle | |
| Middlesbrough | 3-0 | Coventry City | |
| Nottingham Forest | 4-1 | Swindon Town | |
| Peterborough United | 1-1 | Newcastle United | |
| Queens Park Rangers | 4-0 | Wealdstone | |
| Rotherham United | 1-1 | Millwall | |
| Sheffield United | 0-5 | Arsenal | |
| Stoke City | 4-0 | Tilbury | |
| Sunderland | 0-1 | Bristol Rovers | |
| Tottenham Hotspur | 2-2 | Bolton Wanderers | |
| Walsall | 4-1 | Swansea City | |
| West Bromwich Albion | 4-1 | Blackpool | |
| West Ham United | 1-0 | Watford | |
| Monday 9th January 1978 | |||
| Replay | |||
| Wrexham | 3-0 | Bristol City | |
| Tuesday 10th January 1978 | |||
| Replay | |||
| Bolton Wanderers | 2-1 | Tottenham Hotspur | aet |
| Millwall | 2-0 | Rotherham United | |
| Oldham Athletic | 1-2 | Luton Town | |
| Southampton | 0-0 | Grimsby Town | aet |
| Wolverhampton Wndrs | 3-1 | Exeter City | |
| Wednesday 11th January 1978 | |||
| Replay | |||
| Manchester United | 4-2 | Carlisle United | |
| Newcastle United | 2-0 | Peterborough United | |
| Monday 16th January 1978 | |||
| Replay | |||
| Norwich City | 0-1 | Leyton Orient | |
| 2nd Replay | |||
| Grimsby Town | 1-4 | Southampton | (n) |
