| Saturday 28th January 1978 | |||
| Arsenal | 2-1 | Wolverhampton Wndrs | |
| Bristol Rovers | 2-0 | Southampton | |
| Ipswich Town | 4-1 | Hartlepool United | |
| Leyton Orient | 3-1 | Blackburn Rovers | |
| Manchester United | 1-1 | West Bromwich Albion | |
| Middlesbrough | 3-2 | Everton | |
| Newcastle United | 2-2 | Wrexham | |
| Walsall | 1-0 | Leicester City | |
| West Ham United | 1-1 | Queens Park Rangers | |
| Tuesday 31st January 1978 | |||
| Brighton and Hove A | 1-2 | Notts County | |
| Chelsea | 6-2 | Burnley | |
| Millwall | 4-0 | Luton Town | |
| Nottingham Forest | 2-1 | Manchester City | |
| Replay | |||
| Queens Park Rangers | 6-1 | West Ham United | |
| Wednesday 1st February 1978 | |||
| Derby County | 2-1 | Birmingham City | |
| Replay | |||
| West Bromwich Albion | 3-2 | Manchester United | aet |
| Monday 6th February 1978 | |||
| Bolton Wanderers | 1-0 | Mansfield Town | |
| Stoke City | 2-3 | Blyth Spartans | |
| Replay | |||
| Wrexham | 4-1 | Newcastle United | |
