| Saturday 5th January 2013 | |||
| Aldershot Town | 3-1 | Rotherham United | |
| Aston Villa | 2-1 | Ipswich Town | |
| Barnsley | 1-0 | Burnley | |
| Blackburn Rovers | 2-0 | Bristol City | |
| Bolton Wanderers | 2-2 | Sunderland | |
| Brighton and Hove A | 2-0 | Newcastle United | |
| Charlton Athletic | 0-1 | Huddersfield Town | |
| Crawley Town | 1-3 | Reading | |
| Crystal Palace | 0-0 | Stoke City | |
| Derby County | 5-0 | Tranmere Rovers | |
| Fulham | 1-1 | Blackpool | |
| Hull City | 1-1 | Leyton Orient | |
| Leeds United | 1-1 | Birmingham City | |
| Leicester City | 2-0 | Burton Albion | |
| Luton Town | 1-0 | Wolverhampton Wndrs | |
| Macclesfield Town | 2-1 | Cardiff City | |
| Manchester City | 3-0 | Watford | |
| Middlesbrough | 4-1 | Hastings United | |
| Millwall | 1-0 | Preston North End | |
| Nottingham Forest | 2-3 | Oldham Athletic | |
| Oxford United | 0-3 | Sheffield United | |
| Peterborough United | 0-3 | Norwich City | |
| Queens Park Rangers | 1-1 | West Bromwich Albion | |
| Sheffield Wednesday | 0-0 | Milton Keynes Dons | |
| Southampton | 1-5 | Chelsea | |
| Southend United | 2-2 | Brentford | |
| Tottenham Hotspur | 3-0 | Coventry City | |
| West Ham United | 2-2 | Manchester United | |
| Wigan Athletic | 1-1 | Bournemouth | |
| Sunday 6th January 2013 | |||
| Mansfield Town | 1-2 | Liverpool | |
| Swansea City | 2-2 | Arsenal | |
| Monday 7th January 2013 | |||
| Cheltenham Town | 1-5 | Everton | |
| Tuesday 15th January 2013 | |||
| Replay | |||
| Birmingham City | 1-2 | Leeds United | |
| Blackpool | 1-2 | Fulham | aet |
| Bournemouth | 0-1 | Wigan Athletic | |
| Brentford | 2-1 | Southend United | |
| Leyton Orient | 1-2 | Hull City | aet |
| Milton Keynes Dons | 2-0 | Sheffield Wednesday | |
| Stoke City | 4-1 | Crystal Palace | aet |
| Sunderland | 0-2 | Bolton Wanderers | |
| West Bromwich Albion | 0-1 | Queens Park Rangers | |
| Wednesday 16th January 2013 | |||
| Replay | |||
| Arsenal | 1-0 | Swansea City | |
| Manchester United | 1-0 | West Ham United | |
