| Tuesday 21st September 2010 | |||
| Birmingham City | 3-1 | Milton Keynes Dons | |
| Brentford | 1-1 | Everton | aet |
| (Brentford won on penalties) | |||
| Burnley | 1-0 | Bolton Wanderers | |
| Millwall | 1-2 | Ipswich Town | |
| Peterborough United | 1-3 | Swansea City | |
| Portsmouth | 1-2 | Leicester City | |
| Stoke City | 2-0 | Fulham | |
| Sunderland | 1-2 | West Ham United | |
| Tottenham Hotspur | 1-4 | Arsenal | aet |
| Wolverhampton Wndrs | 4-2 | Notts County | aet |
| Wednesday 22nd September 2010 | |||
| Aston Villa | 3-1 | Blackburn Rovers | |
| Chelsea | 3-4 | Newcastle United | |
| Liverpool | 2-2 | Northampton Town | aet |
| (Northampton Town won on penalties) | |||
| Scunthorpe United | 2-5 | Manchester United | |
| West Bromwich Albion | 2-1 | Manchester City | |
| Wigan Athletic | 2-1 | Preston North End | |
