| Wednesday 5th November 2008 | |||
| First Round Group E | |||
| AaB Aalborg | 2-2 | Villarreal | |
| Celtic | 1-1 | Manchester United | |
| First Round Group F | |||
| Fiorentina | 1-1 | Bayern Munich | |
| Lyon | 2-0 | Steaua Bucharest | |
| First Round Group G | |||
| Arsenal | 0-0 | Fenerbahce | |
| Dinamo Kiev | 1-2 | FC Porto | |
| First Round Group H | |||
| BATE Borisov | 0-2 | Zenit St Petersburg | |
| Real Madrid | 0-2 | Juventus | |
| Tuesday 25th November 2008 | |||
| First Round Group E | |||
| AaB Aalborg | v | Celtic | 19:45 |
| Villarreal | v | Manchester United | 19:45 |
| First Round Group F | |||
| Bayern Munich | v | Steaua Bucharest | 19:45 |
| Fiorentina | v | Lyon | 19:45 |
| First Round Group G | |||
| Arsenal | v | Dinamo Kiev | 19:45 |
| Fenerbahce | v | FC Porto | 19:45 |
| First Round Group H | |||
| BATE Borisov | v | Real Madrid | 19:45 |
| Zenit St Petersburg | v | Juventus | 17:30 |
| Wednesday 26th November 2008 | |||
| First Round Group A | |||
| Bordeaux | v | Chelsea | 19:45 |
| CFR Cluj-Napoca | v | Roma | 19:45 |
| First Round Group B | |||
| Anorthosis Famagusta | v | Werder Bremen | 19:45 |
| Inter Milan | v | Panathinaikos | 19:45 |
| First Round Group C | |||
| Shakhtar Donetsk | v | FC Basle | 19:45 |
| Sporting Lisbon | v | Barcelona | 19:45 |
| First Round Group D | |||
| Atletico Madrid | v | PSV Eindhoven | 19:45 |
| Liverpool | v | Marseille | 19:45 |
