| Tuesday 16th August 2011 | |||
| 1st Leg | |||
| Arsenal | 1-0 | Udinese | |
| BATE Borisov | 1-1 | Sturm Graz | |
| FC Copenhagen | 1-3 | Viktoria Plzen | |
| FC Twente Enschede | 2-2 | Benfica | |
| Lyon | 3-1 | Rubin Kazan | |
| Wednesday 17th August 2011 | |||
| 1st Leg | |||
| Bayern Munich | 2-0 | FC Zurich | |
| Dinamo Zagreb | 4-1 | Malmo | |
| Maccabi Haifa | 2-1 | Genk | |
| OB Odense | 1-0 | Villarreal | |
| Wisla Krakow | 1-0 | Apoel Nicosia | |
| Tuesday 23rd August 2011 | |||
| 2nd Leg | |||
| Apoel Nicosia | 3-1 | Wisla Krakow | (3-2) |
| FC Zurich | 0-1 | Bayern Munich | (0-3) |
| Genk | 2-1 | Maccabi Haifa | aet (3-3) |
| (Genk won on penalties) | |||
| Malmo | 2-0 | Dinamo Zagreb | (3-4) |
| Villarreal | 3-0 | OB Odense | (3-1) |
| Wednesday 24th August 2011 | |||
| 2nd Leg | |||
| Benfica | 3-1 | FC Twente Enschede | (5-3) |
| Rubin Kazan | 1-1 | Lyon | (2-4) |
| Sturm Graz | 0-2 | BATE Borisov | (1-3) |
| Udinese | 1-2 | Arsenal | (1-3) |
| Viktoria Plzen | 2-1 | FC Copenhagen | (5-2) |
