| P | W | D | L | F | A | GD | Pt | |
| PSV Eindhoven | 6 | 4 | 2 | 0 | 10 | 3 | +7 | 14 |
| Metalist Kharkiv | 6 | 3 | 2 | 1 | 9 | 4 | +5 | 11 |
| Sampdoria | 6 | 1 | 2 | 3 | 4 | 7 | -3 | 5 |
| Debreceni VSC | 6 | 1 | 0 | 5 | 4 | 13 | -9 | 3 |
| Thursday 16th September 2010 | |||
| Debreceni VSC | 0-5 | Metalist Kharkiv | |
| PSV Eindhoven | 1-1 | Sampdoria | |
| Thursday 30th September 2010 | |||
| Metalist Kharkiv | 0-2 | PSV Eindhoven | |
| Sampdoria | 1-0 | Debreceni VSC | |
| Thursday 21st October 2010 | |||
| Debreceni VSC | 1-2 | PSV Eindhoven | |
| Metalist Kharkiv | 2-1 | Sampdoria | |
| Thursday 4th November 2010 | |||
| PSV Eindhoven | 3-0 | Debreceni VSC | |
| Sampdoria | 0-0 | Metalist Kharkiv | |
| Wednesday 1st December 2010 | |||
| Metalist Kharkiv | 2-1 | Debreceni VSC | |
| Sampdoria | 1-2 | PSV Eindhoven | |
| Thursday 16th December 2010 | |||
| Debreceni VSC | 2-0 | Sampdoria | |
| PSV Eindhoven | 0-0 | Metalist Kharkiv | |
September 2010
| Jul | Aug | Sep | Oct | Nov | Dec |
| Jan | Feb | Mar | Apr | May | Jun |
| Mo | Tu | We | Th | Fr | Sa | Su |
| 1 | 2 | 3 | 4 | 5 | ||
| 6 | 7 | 8 | 9 | 10 | 11 | 12 |
| 13 | 14 | 15 | 16 | 17 | 18 | 19 |
| 20 | 21 | 22 | 23 | 24 | 25 | 26 |
| 27 | 28 | 29 | 30 |
- Final
- Semi-Final
- Quarter-Final
- Third Round
- Second Round
- First Round Group A
- First Round Group B
- First Round Group C
- First Round Group D
- First Round Group E
- First Round Group F
- First Round Group G
- First Round Group H
- First Round Group I
- First Round Group J
- First Round Group K
- First Round Group L
- Qualifying Play-Off
- Third Qualifying Round
- Second Qualifying Round
- First Qualifying Round
