| Tuesday 15th February 2011 | |||
| 1st Leg | |||
| Aris Salonika | 0-0 | Manchester City | |
| Thursday 17th February 2011 | |||
| 1st Leg | |||
| Anderlecht | 0-3 | Ajax | |
| Basle | 2-3 | Spartak Moscow | |
| BATE Borisov | 2-2 | Paris Saint-Germain | |
| Benfica | 2-1 | VfB Stuttgart | |
| Besiktas | 1-4 | Dinamo Kiev | |
| Lech Poznan | 1-0 | Sporting Braga | |
| Lille | 2-2 | PSV Eindhoven | |
| Metalist Kharkiv | 0-4 | Bayer Leverkusen | |
| Napoli | 0-0 | Villarreal | |
| PAOK Salonika | 0-1 | CSKA Moscow | |
| Rangers | 1-1 | Sporting Lisbon | |
| Rubin Kazan | 0-2 | FC Twente Enschede | |
| Seville | 1-2 | FC Porto | |
| Sparta Prague | 0-0 | Liverpool | |
| Young Boys | 2-1 | Zenit St Petersburg | |
| Tuesday 22nd February 2011 | |||
| 2nd Leg | |||
| CSKA Moscow | 1-1 | PAOK Salonika | (2-1) |
| Wednesday 23rd February 2011 | |||
| 2nd Leg | |||
| FC Porto | 0-1 | Seville | (2-2) |
| (FC Porto won on away goals) | |||
| Thursday 24th February 2011 | |||
| 2nd Leg | |||
| Ajax | 2-0 | Anderlecht | (5-0) |
| Bayer Leverkusen | 2-0 | Metalist Kharkiv | (6-0) |
| Dinamo Kiev | 4-0 | Besiktas | (8-1) |
| FC Twente Enschede | 2-2 | Rubin Kazan | (4-2) |
| Liverpool | 1-0 | Sparta Prague | (1-0) |
| Manchester City | 3-0 | Aris Salonika | (3-0) |
| Paris Saint-Germain | 0-0 | BATE Borisov | (2-2) |
| (BATE Borisov won on away goals) | |||
| PSV Eindhoven | 3-1 | Lille | (5-3) |
| Spartak Moscow | 1-1 | Basle | (4-3) |
| Sporting Braga | 2-0 | Lech Poznan | (2-1) |
| Sporting Lisbon | 2-2 | Rangers | (3-3) |
| (Rangers won on away goals) | |||
| VfB Stuttgart | 0-2 | Benfica | (1-4) |
| Villarreal | 2-1 | Napoli | (2-1) |
| Zenit St Petersburg | 3-1 | Young Boys | (4-3) |
February 2011
| Jul | Aug | Sep | Oct | Nov | Dec |
| Jan | Feb | Mar | Apr | May | Jun |
| Mo | Tu | We | Th | Fr | Sa | Su |
| 1 | 2 | 3 | 4 | 5 | 6 | |
| 7 | 8 | 9 | 10 | 11 | 12 | 13 |
| 14 | 15 | 16 | 17 | 18 | 19 | 20 |
| 21 | 22 | 23 | 24 | 25 | 26 | 27 |
| 28 |
- Final
- Semi-Final
- Quarter-Final
- Third Round
- Second Round
- First Round Group A
- First Round Group B
- First Round Group C
- First Round Group D
- First Round Group E
- First Round Group F
- First Round Group G
- First Round Group H
- First Round Group I
- First Round Group J
- First Round Group K
- First Round Group L
- Qualifying Play-Off
- Third Qualifying Round
- Second Qualifying Round
- First Qualifying Round
