| Thursday 6th December 2012 | |||
| First Round Group A | |||
| Udinese | 0-1 | Liverpool | |
| Young Boys | 3-1 | Anzhi Makhachkala | |
| First Round Group B | |||
| Hapoel Tel-Aviv | 2-0 | Academica Coimbra | |
| Viktoria Plzen | 1-0 | Atletico Madrid | |
| First Round Group C | |||
| AEL Limassol | 3-0 | Marseille | |
| Fenerbahce | 0-3 | Borussia Monch'bach | |
| First Round Group D | |||
| Bordeaux | 2-0 | Newcastle United | |
| Maritimo | 2-1 | Club Brugge | |
| First Round Group E | |||
| FC Copenhagen | 1-1 | Steaua Bucharest | |
| VfB Stuttgart | 0-1 | Molde | |
| First Round Group F | |||
| Dnipro Dnipropet'vsk | 4-0 | AIK Stockholm | |
| Napoli | 1-3 | PSV Eindhoven | |
| First Round Group G | |||
| Genk | 0-0 | Basle | |
| First Round Group H | |||
| Inter Milan | 2-2 | Neftchi Baku | |
| Partizan Belgrade | 1-1 | Rubin Kazan | |
| First Round Group I | |||
| Athletic Bilbao | 0-0 | Sparta Prague | |
| Lyon | 2-0 | Hapoel Ironi KS | |
| First Round Group J | |||
| NK Maribor | 1-4 | Lazio | |
| Tottenham Hotspur | 3-1 | Panathinaikos | |
| First Round Group K | |||
| Bayer Leverkusen | 1-0 | Rosenborg | |
| Rapid Vienna | 1-0 | Metalist Kharkiv | |
| First Round Group L | |||
| FC Twente Enschede | 1-3 | Helsingborgs | |
| Levante | 2-2 | Hannover 96 | |
December 2012
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