| Thursday 14th February 2013 | |||
| Second Round 1st Leg | |||
| Ajax | 2-0 | Steaua Bucharest | |
| Anzhi Makhachkala | 3-1 | Hannover 96 | |
| Atletico Madrid | 0-2 | Rubin Kazan | |
| Basle | 2-0 | Dnipro Dnipropet'vsk | |
| BATE Borisov | 0-0 | Fenerbahce | |
| Bayer Leverkusen | 0-1 | Benfica | |
| Borussia Monch'bach | 3-3 | Lazio | |
| Dinamo Kiev | 1-1 | Bordeaux | |
| Inter Milan | 2-0 | CFR Cluj-Napoca | |
| Levante | 3-0 | Olympiakos | |
| Napoli | 0-3 | Viktoria Plzen | |
| Newcastle United | 0-0 | Metalist Kharkiv | |
| Sparta Prague | 0-1 | Chelsea | |
| Tottenham Hotspur | 2-1 | Lyon | |
| VfB Stuttgart | 1-1 | Genk | |
| Zenit St Petersburg | 2-0 | Liverpool | |
February 2013
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