| Thursday 7th March 2013 | |||
| 1st Leg | |||
| Anzhi Makhachkala | 0-0 | Newcastle United | |
| Basle | 2-0 | Zenit St Petersburg | |
| Benfica | 1-0 | Bordeaux | |
| Levante | 0-0 | Rubin Kazan | |
| Steaua Bucharest | 1-0 | Chelsea | |
| Tottenham Hotspur | 3-0 | Inter Milan | |
| VfB Stuttgart | 0-2 | Lazio | |
| Viktoria Plzen | 0-1 | Fenerbahce | |
| Thursday 14th March 2013 | |||
| 2nd Leg | |||
| Bordeaux | 2-3 | Benfica | (2-4) |
| Chelsea | 3-1 | Steaua Bucharest | (3-2) |
| Fenerbahce | 1-1 | Viktoria Plzen | (2-1) |
| Inter Milan | 4-1 | Tottenham Hotspur | aet (4-4) |
| (Tottenham Hotspur won on away goals) | |||
| Lazio | 3-1 | VfB Stuttgart | (5-1) |
| Newcastle United | 1-0 | Anzhi Makhachkala | (1-0) |
| Rubin Kazan | 2-0 | Levante | aet (2-0) |
| Zenit St Petersburg | 1-0 | Basle | (1-2) |
March 2013
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