| Tuesday 21st October 1975 | |||
| 1st Leg | |||
| MSV Duisburg | 3-2 | Levski Spartak Sofia | |
| Wednesday 22nd October 1975 | |||
| 1st Leg | |||
| Athlone Town | 0-0 | AC Milan | |
| Carl Zeiss Jena | 1-0 | Stal Mielec | |
| Dundee United | 1-2 | FC Porto | |
| Galatasaray | 2-4 | Torpedo Moscow | |
| Hertha BSC Berlin | 1-0 | Ajax | |
| Honved | 2-2 | Dynamo Dresden | |
| Inter Bratislava | 2-0 | AEK Athens | |
| Ipswich Town | 3-0 | Club Brugge | |
| Osters | 1-0 | Roma | |
| Real Sociedad | 1-3 | Liverpool | |
| Red Star Belgrade | 1-1 | SV Hamburg | |
| Slask Wroclaw | 1-1 | Royal Antwerp FC | |
| Spartak Moscow | 2-0 | FC Cologne | |
| Vasas Budapest | 3-1 | Sporting Lisbon | |
| Tuesday 4th November 1975 | |||
| 2nd Leg | |||
| Levski Spartak Sofia | 2-1 | MSV Duisburg | (4-4) |
| (Levski Spartak Sofia won on away goals) | |||
| Liverpool | 6-0 | Real Sociedad | (9-1) |
| Wednesday 5th November 1975 | |||
| 2nd Leg | |||
| AC Milan | 3-0 | Athlone Town | (3-0) |
| AEK Athens | 3-1 | Inter Bratislava | (3-3) |
| (Inter Bratislava won on away goals) | |||
| Ajax | 4-1 | Hertha BSC Berlin | (4-2) |
| Barcelona | 4-0 | Lazio | (7-0) |
| Club Brugge | 4-0 | Ipswich Town | (4-3) |
| Dynamo Dresden | 1-0 | Honved | (3-2) |
| FC Cologne | 0-1 | Spartak Moscow | (0-3) |
| FC Porto | 1-1 | Dundee United | (3-2) |
| Roma | 2-0 | Osters | (2-1) |
| Royal Antwerp FC | 1-2 | Slask Wroclaw | (2-3) |
| Sporting Lisbon | 2-1 | Vasas Budapest | (3-4) |
| Stal Mielec | 1-0 | Carl Zeiss Jena | aet (1-1) |
| (Stal Mielec won on penalties) | |||
| SV Hamburg | 4-0 | Red Star Belgrade | (5-1) |
| Torpedo Moscow | 3-0 | Galatasaray | (7-2) |
| 1975-1976 | |||
| 1st Leg | |||
| Lazio | 0-3 | Barcelona | |
| (Barcelona awarded match) | |||
