| Wednesday 26th November 1975 | |||
| 1st Leg | |||
| AC Milan | 4-0 | Spartak Moscow | |
| Ajax | 2-1 | Levski Spartak Sofia | |
| Barcelona | 3-1 | Vasas Budapest | |
| Club Brugge | 1-0 | Roma | |
| Dynamo Dresden | 3-0 | Torpedo Moscow | |
| Inter Bratislava | 1-0 | Stal Mielec | |
| Slask Wroclaw | 1-2 | Liverpool | |
| SV Hamburg | 2-0 | FC Porto | |
| Wednesday 10th December 1975 | |||
| 2nd Leg | |||
| FC Porto | 2-1 | SV Hamburg | (2-3) |
| Levski Spartak Sofia | 2-1 | Ajax | aet (3-3) |
| (Levski Spartak Sofia won on penalties) | |||
| Liverpool | 3-0 | Slask Wroclaw | (5-1) |
| Roma | 0-1 | Club Brugge | (0-2) |
| Spartak Moscow | 2-0 | AC Milan | (2-4) |
| Stal Mielec | 2-0 | Inter Bratislava | (2-1) |
| Torpedo Moscow | 3-1 | Dynamo Dresden | (3-4) |
| Vasas Budapest | 0-1 | Barcelona | (1-4) |
