| Friday 5th September 2008 | |||
| Second Qualifying Round Group 5 | |||
| Libya | 1-0 | Ghana | |
| Second Qualifying Round Group 6 | |||
| Algeria | 2-3 | Senegal | |
| Sunday 7th September 2008 | |||
| Second Qualifying Round Group 8 | |||
| Ethiopia | P-P | Morocco | |
| Friday 5th September 2008 | |||
| Second Qualifying Round Group 12 | |||
| Djibouti | 0-3 | Malawi | |
| Saturday 6th September 2008 | |||
| Second Qualifying Round Group 1 | |||
| Cape Verde Islands | v | Cameroon | 18:00 |
| Mauritius | v | Tanzania | 12:00 |
| Second Qualifying Round Group 2 | |||
| Kenya | v | Namibia | 14:00 |
| Second Qualifying Round Group 4 | |||
| Sierra Leone | v | Equatorial Guinea | 17:30 |
| South Africa | v | Nigeria | 14:00 |
| Second Qualifying Round Group 6 | |||
| Gambia | v | Liberia | 18:00 |
| Second Qualifying Round Group 8 | |||
| Mauritania | v | Rwanda | 18:00 |
| Second Qualifying Round Group 9 | |||
| Burkina Faso | v | Tunisia | 19:00 |
| Seychelles | v | Burundi | 13:30 |
| Second Qualifying Round Group 10 | |||
| Sudan | v | Chad | 21:00 |
| Sunday 7th September 2008 | |||
| Second Qualifying Round Group 2 | |||
| Zimbabwe | v | Guinea | 14:00 |
| Second Qualifying Round Group 3 | |||
| Benin | v | Angola | 16:00 |
| Niger | v | Uganda | 16:30 |
| Second Qualifying Round Group 5 | |||
| Lesotho | v | Gabon | 14:00 |
| Second Qualifying Round Group 7 | |||
| Madagascar | v | Botswana | 12:30 |
| Mozambique | v | Ivory Coast | 14:00 |
| Second Qualifying Round Group 10 | |||
| Congo | v | Mali | 15:30 |
| Second Qualifying Round Group 12 | |||
| Congo DR | v | Egypt | 15:30 |
| Wednesday 10th September 2008 | |||
| Second Qualifying Round Group 10 | |||
| Chad | v | Sudan | 22:00 |
| Second Qualifying Round Group 11 | |||
| Zambia | v | Togo | 13:00 |