| Saturday 28th November 1891 | |||
| Abercorn | 2-3 | Queen's Park | |
| Annbank | 2-1 | Battlefield | |
| Broxburn Shamrock | 7-2 | Northern | |
| Cowlairs | 3-1 | Cambuslang | |
| (match void) | |||
| Dumbarton | 4-0 | Thistle | |
| East Stirlingshire | 1-6 | Kilmarnock | |
| Kilmarnock Athletic | 7-2 | Bridge of Allan | |
| Leith Athletic | 5-0 | Dunblane | |
| Linthouse | 0-6 | Bathgate Rovers | |
| Monkcastle | 3-4 | Arbroath | |
| Rangers | 5-1 | St Bernard's | |
| Renton | 7-4 | Ayr FC | |
| St Mirren | 2-4 | Celtic | |
| Third Lanark | 3-0 | Vale of Leven | |
| Saturday 5th December 1891 | |||
| Aberdeen | 2-6 | Mid-Annandale | |
| Heart of Midlothian | 8-0 | Clyde | |
| Saturday 12th December 1891 | |||
| Replay | |||
| Cowlairs | 3-1 | Cambuslang | |
