| Saturday 22nd October 2011 | |||
| Alloa Athletic | 2-2 | Annan Athletic | |
| Auchinleck Talbot | 8-1 | Threave Rovers | |
| Bo'ness United | 2-1 | Whitehill Welfare | |
| Clachnacuddin | 1-1 | Inverurie Locos | |
| Culter | 0-2 | Spartans | |
| (Culter won - Spartans disqualified) | |||
| Deveronvale | 4-0 | Berwick Rangers | |
| Edinburgh City | 0-1 | Irvine Meadow | |
| Fraserburgh | 0-0 | Elgin City | |
| Gala Fairydean | 5-2 | Golspie Sutherland | |
| Huntly | 0-3 | Queen's Park | |
| Montrose | 2-1 | Clyde | |
| Peterhead | 2-0 | Nairn County | |
| Vale of Leithen | 3-2 | Cove Rangers | |
| Wick Academy | 0-1 | Keith | |
| Wigtown and Bladnoch | 0-9 | Stranraer | |
| Sunday 23rd October 2011 | |||
| East Stirlingshire | 1-1 | Buckie Thistle | |
| Saturday 29th October 2011 | |||
| Replay | |||
| Annan Athletic | 2-0 | Alloa Athletic | |
| Buckie Thistle | 2-4 | East Stirlingshire | aet |
| Elgin City | 5-2 | Fraserburgh | |
| Inverurie Locos | 3-2 | Clachnacuddin | |









