| Saturday 7th January 2012 | |||
| Airdrie United | 2-6 | Dundee United | |
| Cowdenbeath | 2-3 | Hibernian | |
| Dundee | 1-1 | Kilmarnock | |
| Falkirk | 2-0 | East Fife | |
| Forfar Athletic | 0-4 | Aberdeen | |
| Heart of Midlothian | 1-0 | Auchinleck Talbot | |
| Inverness CT | 1-1 | Dunfermline Athletic | |
| Livingston | 1-2 | Ayr United | |
| Motherwell | 4-0 | Queen's Park | |
| Partick Thistle | 0-1 | Queen of the South | |
| Raith Rovers | 1-2 | Morton | |
| Ross County | 7-0 | Stenhousemuir | |
| St Johnstone | 2-1 | Brechin City | |
| St Mirren | 0-0 | Hamilton Academical | |
| Sunday 8th January 2012 | |||
| Arbroath | 0-4 | Rangers | |
| Peterhead | 0-3 | Celtic | |
| Tuesday 17th January 2012 | |||
| Replay | |||
| Hamilton Academical | 0-1 | St Mirren | |
| Kilmarnock | 2-1 | Dundee | |
| Wednesday 18th January 2012 | |||
| Replay | |||
| Dunfermline Athletic | 1-3 | Inverness CT | aet |
