Grimsby record their first league win since the opening day by thrashing Stevenage, as Omar Bogle claims a hat-trick.
Grimsby pair Rhys Browne and Dan Jones have both been ruled out of the home game against Stevenage.
Liam Kelly and Ollie Palmer score for Leyton Orient to consign Grimsby to a fourth successive defeat in all competitions.
Skipper Craig Disley is in line to return to Grimsby's starting XI against Leyton Orient after coming off the bench to score at Colchester on Tuesday following his recovery from a concussion sustained in pre-season.
Brennan Dickenson scores twice as Colchester resist a spirited Grimsby fightback to record their second successive win.
Colchester have no fresh injury concerns ahead of the visit of Grimsby to the Weston Homes Community Stadium for their Sky Bet League Two clash.
Adebayo Akinfenwa hit both posts for Wycombe in their 2-1 win over Grimsby on Saturday.
Anthony Stewart's injury-time winner against Grimsby earns Wycombe their first victory since March.