Paris St-Germain fail to replicate their midweek display against Barcelona as they are held at home by Toulouse in Ligue 1.
Lionel Messi's late penalty sees off the challenge of Leganes and spares Barcelona from a second successive embarrassing result.
Chelsea are free to focus on the FA Cup as they are certain to win the Premier League, Manchester United boss Jose Mourinho says.
"I knew the contribution would be massive," Jose Mourinho said on Sunday, when asked whether Zlatan Ibrahimovic had exceeded his expectations at Manchester United this season.
Watch the FA Cup fifth round's best goals, including Rudy Gestede's acrobatic volley for Middlesbrough and a lovely finish from Blackburn's Danny Graham.
New coach Zdenek Zeman leads Pescara to their first win since August - a stunning 5-0 victory over Genoa.
Manchester United manager Jose Mourinho says his side had to work hard to beat "brave" Championship strugglers Blackburn 2-1 in the FA Cup fifth round.
Lincoln City will play Sutton or Arsenal in the FA Cup quarter-finals as reward for their fifth-round victory over Burnley.