| Friday 5th December 1997 | |||
| Chester City | 0-2 | Wrexham | |
| Saturday 6th December 1997 | |||
| Cambridge United | 1-1 | Stevenage | |
| Cardiff City | 3-1 | Hendon | |
| Cheltenham Town | 1-1 | Boreham Wood | |
| Colchester United | 1-1 | Hereford United | |
| Fulham | 1-0 | Southend United | |
| Grimsby Town | 2-2 | Chesterfield | |
| Hednesford Town | 0-1 | Darlington | |
| Lincoln City | 2-2 | Wakefield-Emley | |
| Macclesfield Town | 0-7 | Walsall | |
| Northampton Town | 1-1 | Basingstoke Town | |
| Oldham Athletic | 2-1 | Blackpool | |
| Peterborough United | 3-2 | Dagenham and Redb'ge | |
| Preston North End | 2-2 | Notts County | |
| Rotherham United | 6-0 | King's Lynn | |
| Scunthorpe United | 1-1 | Ilkeston Town | |
| Torquay United | 1-1 | Watford | |
| Wigan Athletic | 2-1 | York City | |
| Wisbech Town | 0-2 | Bristol Rovers | |
| Sunday 7th December 1997 | |||
| Bournemouth | 3-1 | Bristol City | |
| Monday 15th December 1997 | |||
| Replay | |||
| Stevenage | 2-1 | Cambridge United | |
| Tuesday 16th December 1997 | |||
| Replay | |||
| Basingstoke Town | 0-0 | Northampton Town | aet |
| (Northampton Town won on penalties) | |||
| Boreham Wood | 0-2 | Cheltenham Town | |
| Chesterfield | 0-2 | Grimsby Town | |
| Hereford United | 1-1 | Colchester United | aet |
| (Hereford United won on penalties) | |||
| Notts County | 1-2 | Preston North End | aet |
| Watford | 2-1 | Torquay United | aet |
| Wednesday 17th December 1997 | |||
| Replay | |||
| Ilkeston Town | 1-2 | Scunthorpe United | |
| Wakefield-Emley | 3-3 | Lincoln City | aet |
| (Wakefield-Emley won on penalties) | |||
