| Wednesday 13th September 1967 | |||
| 1st Leg | |||
| Besiktas | 0-1 | Rapid Vienna | |
| Glentoran | 1-1 | Benfica | |
| Sunday 17th September 1967 | |||
| 1st Leg | |||
| Valur Reykjavik | 1-1 | Jeunesse Esch | |
| Tuesday 19th September 1967 | |||
| 2nd Leg | |||
| Rapid Vienna | 3-0 | Besiktas | (4-0) |
| Wednesday 20th September 1967 | |||
| 1st Leg | |||
| Ajax | 1-1 | Real Madrid | |
| Basle | 1-2 | Hvidovre | |
| Celtic | 1-2 | Dinamo Kiev | |
| Dundalk | 0-1 | Vasas Budapest | |
| Gornik Zabrze | 3-0 | Djurgardens | |
| Karl-Marx-Stadt | 1-3 | Anderlecht | |
| Manchester United | 4-0 | Hibernians | |
| Olympiakos | 0-0 | Juventus | |
| Olympiakos Nicosia | 2-2 | Sarajevo | |
| Saint-Etienne | 2-0 | KuPS Kuopio | |
| Skeid Oslo | 0-1 | Sparta Prague | |
| Wednesday 27th September 1967 | |||
| 1st Leg | |||
| Botev Plovdiv | 2-0 | Rapid Bucharest | |
| 2nd Leg | |||
| Hibernians | 0-0 | Manchester United | (0-4) |
| Sunday 1st October 1967 | |||
| 2nd Leg | |||
| Jeunesse Esch | 3-3 | Valur Reykjavik | (4-4) |
| (Valur Reykjavik won on away goals) | |||
| Wednesday 4th October 1967 | |||
| 2nd Leg | |||
| Benfica | 0-0 | Glentoran | (1-1) |
| (Benfica won on away goals) | |||
| Dinamo Kiev | 1-1 | Celtic | (3-2) |
| Djurgardens | 0-1 | Gornik Zabrze | (0-4) |
| KuPS Kuopio | 0-3 | Saint-Etienne | (0-5) |
| Sparta Prague | 1-1 | Skeid Oslo | (2-1) |
| Wednesday 11th October 1967 | |||
| 2nd Leg | |||
| Juventus | 2-0 | Olympiakos | (2-0) |
| Rapid Bucharest | 3-0 | Botev Plovdiv | (3-2) |
| Real Madrid | 2-1 | Ajax | (3-2) |
| Vasas Budapest | 8-1 | Dundalk | (9-1) |
| Wednesday 18th October 1967 | |||
| 2nd Leg | |||
| Anderlecht | 2-1 | Karl-Marx-Stadt | (5-2) |
| Hvidovre | 3-3 | Basle | (5-4) |
| Sarajevo | 3-1 | Olympiakos Nicosia | (5-3) |
