| Tuesday 17th September 1991 | |||
| 1st Leg | |||
| Kaiserslautern | 2-0 | Etar Veliko Tarnovo | |
| Red Star Belgrade | 4-0 | Portadown | |
| Wednesday 18th September 1991 | |||
| 1st Leg | |||
| Anderlecht | 1-1 | Grasshoppers | |
| Arsenal | 6-1 | Austria Vienna | |
| Barcelona | 3-0 | Hansa Rostock | |
| Besiktas | 1-1 | PSV Eindhoven | |
| Brondby | 3-0 | Zaglebie Lubin | |
| Fram Reykjavik | 2-2 | Panathinaikos | |
| Hamrun Spartans | 0-6 | Benfica | |
| HJK Helsinki | 0-1 | Dinamo Kiev | |
| Honved | 1-1 | Dundalk | |
| IFK Gothenburg | 0-0 | Flamurtari Vlore | |
| Sampdoria | 5-0 | Rosenborg | |
| Sparta Prague | 1-0 | Rangers | |
| Universitata Craiova | 2-0 | Apollon Limassol | |
| US Luxembourg | 0-5 | Marseille | |
| Wednesday 2nd October 1991 | |||
| 2nd Leg | |||
| Apollon Limassol | 3-0 | Universitata Craiova | (3-2) |
| Austria Vienna | 1-0 | Arsenal | (2-6) |
| Benfica | 4-0 | Hamrun Spartans | (10-0) |
| Dinamo Kiev | 3-0 | HJK Helsinki | (4-0) |
| Dundalk | 0-2 | Honved | (1-3) |
| Etar Veliko Tarnovo | 1-1 | Kaiserslautern | (1-3) |
| Flamurtari Vlore | 1-1 | IFK Gothenburg | (1-1) |
| (IFK Gothenburg won on away goals) | |||
| Grasshoppers | 0-3 | Anderlecht | (1-4) |
| Hansa Rostock | 1-0 | Barcelona | (1-3) |
| Marseille | 5-0 | US Luxembourg | (10-0) |
| Panathinaikos | 0-0 | Fram Reykjavik | (2-2) |
| (Panathinaikos won on away goals) | |||
| Portadown | 0-4 | Red Star Belgrade | (0-8) |
| PSV Eindhoven | 2-1 | Besiktas | (3-2) |
| Rangers | 2-1 | Sparta Prague | aet (2-2) |
| (Sparta Prague won on away goals) | |||
| Rosenborg | 1-2 | Sampdoria | (1-7) |
| Zaglebie Lubin | 2-1 | Brondby | (2-4) |
