| Wednesday 13th August 1997 | |||
| 1st Leg | |||
| Anorthosis Famagusta | 2-0 | Lierse | |
| Barcelona | 3-2 | Skonto Riga | |
| Bayer Leverkusen | 6-1 | Dinamo Tbilisi | |
| Beitar Jerusalem | 0-0 | Sporting Lisbon | |
| Besiktas | 0-0 | Maribor Branik | |
| Brondby | 2-4 | Dinamo Kiev | |
| Feyenoord | 6-2 | Jazz Pori | |
| IFK Gothenburg | 3-0 | Rangers | |
| Kosice | 2-1 | Spartak Moscow | |
| MTK Budapest | 3-2 | Rosenborg | |
| (match void) | |||
| Newcastle United | 2-1 | Croatia Zagreb | |
| Olympiakos | 5-0 | MPKC Mozyr | |
| Salzburg | 0-0 | Sparta Prague | |
| Sion | 1-4 | Galatasaray | |
| Steaua Bucharest | 3-0 | Paris Saint-Germain | |
| (Steaua Bucharest awarded match) | |||
| Widzew Lodz | 1-3 | Parma | |
| Thursday 14th August 1997 | |||
| 1st Leg | |||
| MTK Budapest | 0-1 | Rosenborg | |
| Wednesday 27th August 1997 | |||
| 2nd Leg | |||
| Croatia Zagreb | 2-2 | Newcastle United | aet (3-4) |
| Dinamo Kiev | 0-1 | Brondby | (4-3) |
| Dinamo Tbilisi | 1-0 | Bayer Leverkusen | (2-6) |
| Galatasaray | 4-1 | Sion | (8-2) |
| Jazz Pori | 1-2 | Feyenoord | (3-8) |
| Lierse | 3-0 | Anorthosis Famagusta | (3-2) |
| Maribor Branik | 1-3 | Besiktas | (1-3) |
| MPKC Mozyr | 2-2 | Olympiakos | (2-7) |
| Paris Saint-Germain | 5-0 | Steaua Bucharest | (5-3) |
| Parma | 4-0 | Widzew Lodz | (7-1) |
| Rangers | 1-1 | IFK Gothenburg | (1-4) |
| Rosenborg | 3-1 | MTK Budapest | (4-1) |
| (MTK Budapest won on away goals) | |||
| Skonto Riga | 0-1 | Barcelona | (2-4) |
| Sparta Prague | 3-0 | Salzburg | (3-0) |
| Spartak Moscow | 0-0 | Kosice | (1-2) |
| Sporting Lisbon | 3-0 | Beitar Jerusalem | (3-0) |
