| Saturday 15th January 1972 | |||
| Birmingham City | 3-0 | Port Vale | |
| Blackpool | 0-1 | Chelsea | |
| Blyth Spartans | 2-2 | Reading | |
| Bolton Wanderers | 2-1 | Torquay United | |
| Boston United | 0-1 | Portsmouth | |
| Burnley | 0-1 | Huddersfield Town | |
| Bury | 1-1 | Rotherham United | |
| Charlton Athletic | 0-0 | Tranmere Rovers | |
| Crystal Palace | 2-2 | Everton | |
| Derby County | 2-0 | Shrewsbury Town | |
| Leeds United | 4-1 | Bristol Rovers | |
| Leyton Orient | 3-0 | Wrexham | |
| Manchester City | 1-1 | Middlesbrough | |
| Millwall | 3-1 | Nottingham Forest | |
| Norwich City | 0-3 | Hull City | |
| Oxford United | 0-3 | Liverpool | |
| Peterborough United | 0-2 | Ipswich Town | |
| Preston North End | 4-2 | Bristol City | |
| Queens Park Rangers | 1-1 | Fulham | |
| Sheffield United | 1-3 | Cardiff City | |
| Southampton | 1-1 | Manchester United | |
| Stoke City | 2-1 | Chesterfield | |
| Sunderland | 3-0 | Sheffield Wednesday | |
| Swansea City | 1-0 | Gillingham | |
| Swindon Town | 0-2 | Arsenal | |
| Tottenham Hotspur | 1-1 | Carlisle United | |
| Walsall | 1-0 | Bournemouth | |
| Watford | 1-4 | Notts County | |
| West Bromwich Albion | 1-2 | Coventry City | |
| West Ham United | 2-1 | Luton Town | |
| Wolverhampton Wndrs | 1-1 | Leicester City | |
| Monday 17th January 1972 | |||
| Replay | |||
| Tranmere Rovers | 4-2 | Charlton Athletic | |
| Tuesday 18th January 1972 | |||
| Replay | |||
| Carlisle United | 1-3 | Tottenham Hotspur | |
| Everton | 3-2 | Crystal Palace | |
| Fulham | 2-1 | Queens Park Rangers | |
| Middlesbrough | 1-0 | Manchester City | |
| Wednesday 19th January 1972 | |||
| Replay | |||
| Leicester City | 2-0 | Wolverhampton Wndrs | |
| Manchester United | 4-1 | Southampton | aet |
| Reading | 6-1 | Blyth Spartans | |
| Monday 24th January 1972 | |||
| Newcastle United | 2-2 | Hereford United | |
| Replay | |||
| Rotherham United | 2-1 | Bury | |
| Saturday 5th February 1972 | |||
| Replay | |||
| Hereford United | 2-1 | Newcastle United | |
