| Saturday 5th February 1972 | |||
| Birmingham City | 1-0 | Ipswich Town | |
| Chelsea | 3-0 | Bolton Wanderers | |
| Derby County | 6-0 | Notts County | |
| Everton | 2-1 | Walsall | |
| Huddersfield Town | 3-0 | Fulham | |
| Leicester City | 0-2 | Leyton Orient | |
| Liverpool | 0-0 | Leeds United | |
| Millwall | 2-2 | Middlesbrough | |
| Portsmouth | 2-0 | Swansea City | |
| Preston North End | 0-2 | Manchester United | |
| Reading | 1-2 | Arsenal | |
| Tottenham Hotspur | 2-0 | Rotherham United | |
| Tranmere Rovers | 2-2 | Stoke City | |
| Tuesday 8th February 1972 | |||
| Replay | |||
| Middlesbrough | 2-1 | Millwall | |
| Wednesday 9th February 1972 | |||
| Cardiff City | 1-1 | Sunderland | |
| Coventry City | 0-1 | Hull City | |
| Hereford United | 0-0 | West Ham United | |
| Replay | |||
| Leeds United | 2-0 | Liverpool | |
| Stoke City | 2-0 | Tranmere Rovers | |
| Monday 14th February 1972 | |||
| Replay | |||
| Sunderland | 1-1 | Cardiff City | aet |
| West Ham United | 3-1 | Hereford United | |
| Wednesday 16th February 1972 | |||
| 2nd Replay | |||
| Cardiff City | 3-1 | Sunderland | (n) |
