| Tuesday 12th September 1967 | |||
| Burnley | 2-1 | Cardiff City | |
| Coventry City | 1-2 | Arsenal | |
| Grimsby Town | 2-2 | Bury | |
| Huddersfield Town | 1-0 | Wolverhampton Wndrs | |
| Ipswich Town | 5-2 | Southampton | |
| Newport County | 0-1 | Blackpool | |
| Queens Park Rangers | 2-1 | Hull City | |
| Wednesday 13th September 1967 | |||
| Barrow | 1-0 | Crystal Palace | |
| Blackburn Rovers | 3-1 | Brighton and Hove A | |
| Bristol City | 0-5 | Everton | |
| Carlisle United | 0-2 | Workington | |
| Derby County | 4-0 | Hartlepool United | |
| Fulham | 1-0 | Tranmere Rovers | |
| Gillingham | 2-2 | Torquay United | |
| Leeds United | 3-1 | Luton Town | |
| Lincoln City | 2-1 | Newcastle United | |
| Liverpool | 1-1 | Bolton Wanderers | |
| Manchester City | 4-0 | Leicester City | |
| Middlesbrough | 2-1 | Chelsea | |
| Millwall | 3-2 | Sheffield United | |
| Northampton Town | 3-1 | Aston Villa | |
| Norwich City | 1-1 | Rotherham United | |
| Oxford United | 2-1 | Preston North End | |
| Plymouth Argyle | 0-2 | Birmingham City | |
| Portsmouth | 3-1 | Port Vale | |
| Reading | 3-1 | West Bromwich Albion | |
| Scunthorpe United | 0-1 | Nottingham Forest | |
| Southend United | 1-2 | Darlington | |
| Stockport County | 3-5 | Sheffield Wednesday | |
| Stoke City | 2-0 | Watford | |
| Sunderland | 3-2 | Halifax Town | |
| Walsall | 1-5 | West Ham United | |
| Tuesday 19th September 1967 | |||
| Replay | |||
| Bury | 2-0 | Grimsby Town | |
| Rotherham United | 0-2 | Norwich City | |
| Wednesday 20th September 1967 | |||
| Replay | |||
| Torquay United | 2-0 | Gillingham | |
| Wednesday 27th September 1967 | |||
| Replay | |||
| Bolton Wanderers | 3-2 | Liverpool | |
