| Tuesday 10th October 1967 | |||
| Burnley | 3-0 | Nottingham Forest | |
| Queens Park Rangers | 5-1 | Oxford United | |
| Wednesday 11th October 1967 | |||
| Arsenal | 1-0 | Reading | |
| Blackburn Rovers | 3-2 | Middlesbrough | |
| Darlington | 4-1 | Portsmouth | |
| Derby County | 3-1 | Birmingham City | |
| Everton | 2-3 | Sunderland | |
| Leeds United | 3-0 | Bury | |
| Lincoln City | 4-2 | Torquay United | |
| Manchester City | 1-1 | Blackpool | |
| Northampton Town | 0-0 | Millwall | |
| Norwich City | 0-1 | Huddersfield Town | |
| Sheffield Wednesday | 3-1 | Barrow | |
| Stoke City | 2-1 | Ipswich Town | |
| West Ham United | 4-1 | Bolton Wanderers | |
| Workington | 2-2 | Fulham | |
| Monday 16th October 1967 | |||
| Replay | |||
| Fulham | 6-2 | Workington | |
| Millwall | 5-1 | Northampton Town | |
| Wednesday 18th October 1967 | |||
| Replay | |||
| Blackpool | 0-2 | Manchester City | |
