| Tuesday 5th September 1972 | |||
| Arsenal | 1-0 | Everton | |
| Birmingham City | 1-1 | Luton Town | |
| Bristol Rovers | 4-0 | Brighton and Hove A | |
| Bury | 1-0 | Grimsby Town | |
| Carlisle United | 1-1 | Liverpool | |
| Charlton Athletic | 4-3 | Mansfield Town | |
| Coventry City | 1-0 | Hartlepool United | |
| Crystal Palace | 0-1 | Stockport County | |
| Gillingham | 0-2 | Millwall | |
| Hull City | 1-0 | Fulham | |
| Middlesbrough | 2-0 | Wrexham | |
| Newport County | 0-3 | Ipswich Town | |
| Nottingham Forest | 0-1 | Aston Villa | |
| Port Vale | 1-3 | Newcastle United | |
| Rotherham United | 2-0 | Brentford | |
| Southampton | 0-0 | Chester City | |
| Swindon Town | 0-1 | Derby County | |
| Wolverhampton Wndrs | 2-1 | Leyton Orient | |
| Wednesday 6th September 1972 | |||
| Bournemouth | 0-0 | Blackpool | |
| Leeds United | 4-0 | Burnley | |
| Manchester City | 4-0 | Rochdale | |
| Norwich City | 2-1 | Leicester City | |
| Notts County | 3-2 | Southport | |
| Oxford United | 2-2 | Manchester United | |
| Portsmouth | 0-1 | Chesterfield | |
| Sheffield Wednesday | 2-0 | Bolton Wanderers | |
| Southend United | 0-1 | Chelsea | |
| Stoke City | 3-0 | Sunderland | |
| Tottenham Hotspur | 2-1 | Huddersfield Town | |
| West Bromwich Albion | 2-1 | Queens Park Rangers | |
| West Ham United | 2-1 | Bristol City | |
| Workington | 0-1 | Sheffield United | |
| Monday 11th September 1972 | |||
| Replay | |||
| Blackpool | 1-1 | Bournemouth | aet |
| Tuesday 12th September 1972 | |||
| Replay | |||
| Manchester United | 3-1 | Oxford United | |
| Wednesday 13th September 1972 | |||
| Replay | |||
| Chester City | 2-2 | Southampton | aet |
| Luton Town | 1-1 | Birmingham City | aet |
| Monday 18th September 1972 | |||
| 2nd Replay | |||
| Bournemouth | 1-2 | Blackpool | (n) aet |
| Tuesday 19th September 1972 | |||
| Replay | |||
| Liverpool | 5-1 | Carlisle United | |
| 2nd Replay | |||
| Birmingham City | 1-0 | Luton Town | (n) |
| Wednesday 20th September 1972 | |||
| 2nd Replay | |||
| Southampton | 2-0 | Chester City | (n) |
