| Saturday 12th August 1978 | |||
| 1st Leg | |||
| Aldershot | 0-1 | Millwall | |
| Barnsley | 1-2 | Chesterfield | |
| Bournemouth | 0-1 | Exeter City | |
| Bradford City | 2-0 | Lincoln City | |
| Bristol Rovers | 2-1 | Hereford United | |
| Cambridge United | 2-2 | Northampton Town | |
| Cardiff City | 1-2 | Oxford United | |
| Carlisle United | 2-2 | Blackpool | |
| Colchester United | 2-3 | Charlton Athletic | |
| Crewe Alexandra | 1-0 | Rochdale | |
| Doncaster Rovers | 0-1 | Sheffield Wednesday | |
| Grimsby Town | 2-0 | York City | |
| Hull City | 0-1 | Peterborough United | |
| Mansfield Town | 0-1 | Darlington | |
| Newport County | 2-1 | Swansea City | |
| Plymouth Argyle | 1-1 | Torquay United | |
| Port Vale | 0-3 | Chester City | |
| Portsmouth | 0-0 | Swindon Town | |
| Preston North End | 3-0 | Huddersfield Town | |
| Reading | 3-1 | Gillingham | |
| Rotherham United | 5-0 | Hartlepool United | |
| Scunthorpe United | 0-1 | Notts County | |
| Southend United | 1-0 | Wimbledon | |
| Tranmere Rovers | 1-1 | Wigan Athletic | |
| Walsall | 2-1 | Halifax Town | |
| Watford | 4-0 | Brentford | |
| Wrexham | 2-0 | Bury | |
| Monday 14th August 1978 | |||
| 1st Leg | |||
| Shrewsbury Town | 1-0 | Stockport County | |
| 2nd Leg | |||
| Rochdale | 2-4 | Crewe Alexandra | (2-5) |
| Tuesday 15th August 1978 | |||
| 2nd Leg | |||
| Brentford | 1-3 | Watford | (1-7) |
| Bury | 1-2 | Wrexham | (1-4) |
| Charlton Athletic | 0-0 | Colchester United | (3-2) |
| Darlington | 2-2 | Mansfield Town | (3-2) |
| Exeter City | 1-1 | Bournemouth | (2-1) |
| Gillingham | 1-2 | Reading | (2-5) |
| Halifax Town | 0-2 | Walsall | (1-4) |
| Hartlepool United | 1-1 | Rotherham United | (1-6) |
| Huddersfield Town | 2-2 | Preston North End | (2-5) |
| Notts County | 3-0 | Scunthorpe United | (4-0) |
| Peterborough United | 1-2 | Hull City | (2-2) |
| Sheffield Wednesday | 0-1 | Doncaster Rovers | (1-1) |
| Swansea City | 5-0 | Newport County | (6-2) |
| Swindon Town | 4-2 | Portsmouth | (4-2) |
| Wimbledon | 4-1 | Southend United | (4-2) |
| York City | 0-3 | Grimsby Town | (0-5) |
| Wednesday 16th August 1978 | |||
| 2nd Leg | |||
| Blackpool | 2-1 | Carlisle United | (4-3) |
| Chester City | 1-1 | Port Vale | (4-1) |
| Chesterfield | 0-0 | Barnsley | (2-1) |
| Hereford United | 4-0 | Bristol Rovers | (5-2) |
| Lincoln City | 1-1 | Bradford City | (1-3) |
| Millwall | 1-0 | Aldershot | (2-0) |
| Northampton Town | 2-1 | Cambridge United | (4-3) |
| Oxford United | 2-1 | Cardiff City | (4-2) |
| Stockport County | 3-1 | Shrewsbury Town | (3-2) |
| Torquay United | 1-2 | Plymouth Argyle | (2-3) |
| Wigan Athletic | 2-1 | Tranmere Rovers | (3-2) |
| Tuesday 22nd August 1978 | |||
| Replay | |||
| Doncaster Rovers | 0-1 | Sheffield Wednesday | |
| Hull City | 0-1 | Peterborough United | |
