| Monday 28th August 1978 | |||
| Sheffield United | 1-0 | Liverpool | |
| Tuesday 29th August 1978 | |||
| Birmingham City | 2-5 | Southampton | |
| Bolton Wanderers | 2-1 | Chelsea | |
| Brighton and Hove A | 1-0 | Millwall | |
| Bristol City | 1-2 | Crystal Palace | |
| Burnley | 1-1 | Bradford City | |
| Everton | 8-0 | Wimbledon | |
| Exeter City | 2-1 | Blackburn Rovers | |
| Fulham | 2-2 | Darlington | |
| Leyton Orient | 1-2 | Chesterfield | |
| Luton Town | 2-0 | Wigan Athletic | |
| Manchester City | 2-0 | Grimsby Town | |
| Middlesbrough | 0-0 | Peterborough United | |
| Northampton Town | 0-0 | Hereford United | |
| Oldham Athletic | 0-0 | Nottingham Forest | |
| Preston North End | 1-3 | Queens Park Rangers | |
| Rotherham United | 3-1 | Arsenal | |
| Swansea City | 2-2 | Tottenham Hotspur | |
| Walsall | 1-2 | Charlton Athletic | |
| Watford | 2-1 | Newcastle United | |
| West Bromwich Albion | 0-0 | Leeds United | |
| Wrexham | 1-3 | Norwich City | |
| Wednesday 30th August 1978 | |||
| Aston Villa | 1-0 | Sheffield Wednesday | |
| Blackpool | 2-0 | Ipswich Town | |
| Chester City | 2-1 | Coventry City | |
| Crewe Alexandra | 2-0 | Notts County | |
| Leicester City | 0-1 | Derby County | |
| Manchester United | 3-2 | Stockport County | |
| Oxford United | 1-1 | Plymouth Argyle | |
| Reading | 1-0 | Wolverhampton Wndrs | |
| Sunderland | 0-2 | Stoke City | |
| West Ham United | 1-2 | Swindon Town | |
| Tuesday 5th September 1978 | |||
| Replay | |||
| Bradford City | 2-3 | Burnley | |
| Darlington | 1-0 | Fulham | |
| Peterborough United | 1-0 | Middlesbrough | aet |
| Plymouth Argyle | 1-2 | Oxford United | aet |
| Wednesday 6th September 1978 | |||
| Replay | |||
| Hereford United | 0-1 | Northampton Town | |
| Leeds United | 0-0 | West Bromwich Albion | aet |
| Nottingham Forest | 4-2 | Oldham Athletic | |
| Tottenham Hotspur | 1-3 | Swansea City | |
| Monday 2nd October 1978 | |||
| 2nd Replay | |||
| West Bromwich Albion | 0-1 | Leeds United | (n) |
