| Friday 28th January 2011 | |||
| Colchester United | v | Peterborough United | 19:45 |
| Saturday 29th January 2011 | |||
| Brentford | v | Yeovil Town | 15:00 |
| Carlisle United | v | Oldham Athletic | 15:00 |
| Plymouth Argyle | v | Bournemouth | 15:00 |
| Rochdale | v | Charlton Athletic | 15:00 |
| Swindon Town | v | Exeter City | 15:00 |
| Walsall | v | Bristol Rovers | 15:00 |
| Tuesday 1st February 2011 | |||
| Bournemouth | v | Swindon Town | 19:45 |
| Charlton Athletic | v | Colchester United | 19:45 |
| Dagenham and Redb'ge | v | Brentford | 19:45 |
| Exeter City | v | Southampton | 19:45 |
| Huddersfield Town | v | Carlisle United | 19:45 |
| Leyton Orient | v | Brighton and Hove A | 19:45 |
| Oldham Athletic | v | Hartlepool United | 19:45 |
| Peterborough United | v | Sheffield Wednesday | 19:45 |
| Tranmere Rovers | v | Rochdale | 19:45 |
| Yeovil Town | v | Plymouth Argyle | 19:45 |
| Wednesday 2nd February 2011 | |||
| Bristol Rovers | v | Milton Keynes Dons | 19:45 |
| Notts County | v | Walsall | 19:45 |
