| Saturday 12th December 1970 | |||
| Aldershot | 1-1 | Bristol Rovers | |
| Boston United | 1-2 | York City | |
| Bournemouth | 0-1 | Yeovil Town | |
| Brentford | 1-0 | Walsall | |
| Bury | 1-1 | Notts County | |
| Chelmsford City | 0-1 | Torquay United | |
| Chester City | 1-0 | Crewe Alexandra | |
| Chesterfield | 0-0 | Workington | |
| Colchester United | 3-0 | Cambridge United | |
| Darlington | 0-2 | Rochdale | |
| Grantham Town | 1-4 | Rotherham United | |
| Hereford United | 1-2 | Brighton and Hove A | |
| Lincoln City | 2-2 | Bradford City | |
| Rhyl | 0-0 | Barnsley | |
| Scunthorpe United | 3-0 | Mansfield Town | |
| Shrewsbury Town | 2-2 | Reading | |
| Slough Town | 0-1 | Barnet | |
| Southend United | 1-0 | Dagenham | |
| Swansea City | 6-2 | Telford United | |
| Wigan Athletic | 2-1 | Peterborough United | |
| Tuesday 15th December 1970 | |||
| Replay | |||
| Barnsley | 1-1 | Rhyl | aet |
| Bristol Rovers | 1-3 | Aldershot | |
| Wednesday 16th December 1970 | |||
| Replay | |||
| Bradford City | 2-2 | Lincoln City | aet |
| Workington | 3-2 | Chesterfield | |
| Monday 21st December 1970 | |||
| Replay | |||
| Notts County | 3-0 | Bury | |
| Reading | 1-0 | Shrewsbury Town | |
| 2nd Replay | |||
| Lincoln City | 4-1 | Bradford City | (n) |
| Rhyl | 2-0 | Barnsley | (n) |
