| Saturday 23rd January 1971 | |||
| Cardiff City | 0-2 | Brentford | |
| Carlisle United | 2-3 | Tottenham Hotspur | |
| Chelsea | 0-3 | Manchester City | |
| Derby County | 2-1 | Wolverhampton Wndrs | |
| Everton | 3-0 | Middlesbrough | |
| Hull City | 2-0 | Blackpool | |
| Leeds United | 4-0 | Swindon Town | |
| Liverpool | 3-0 | Swansea City | |
| Nottingham Forest | 1-1 | Leyton Orient | |
| Oxford United | 1-1 | Watford | |
| Portsmouth | 1-1 | Arsenal | |
| Rochdale | 3-3 | Colchester United | |
| Stoke City | 3-3 | Huddersfield Town | |
| West Bromwich Albion | 1-1 | Ipswich Town | |
| York City | 3-3 | Southampton | |
| Monday 25th January 1971 | |||
| Leicester City | 3-0 | Torquay United | |
| Replay | |||
| Colchester United | 5-0 | Rochdale | |
| Tuesday 26th January 1971 | |||
| Replay | |||
| Huddersfield Town | 0-0 | Stoke City | aet |
| Ipswich Town | 3-0 | West Bromwich Albion | |
| Wednesday 27th January 1971 | |||
| Replay | |||
| Watford | 1-2 | Oxford United | |
| Monday 1st February 1971 | |||
| Replay | |||
| Arsenal | 3-2 | Portsmouth | |
| Leyton Orient | 0-1 | Nottingham Forest | |
| Southampton | 3-2 | York City | |
| Monday 8th February 1971 | |||
| 2nd Replay | |||
| Stoke City | 1-0 | Huddersfield Town | (n) |
