| Saturday 2nd January 1971 | |||
| Blackpool | 4-0 | West Ham United | |
| Cardiff City | 1-0 | Brighton and Hove A | |
| Chester City | 1-2 | Derby County | |
| Crystal Palace | 2-2 | Chelsea | |
| Everton | 2-0 | Blackburn Rovers | |
| Huddersfield Town | 1-1 | Birmingham City | |
| Hull City | 3-0 | Charlton Athletic | |
| Leicester City | 2-0 | Notts County | |
| Liverpool | 1-0 | Aldershot | |
| Manchester City | 1-0 | Wigan Athletic | |
| Manchester United | 0-0 | Middlesbrough | |
| Nottingham Forest | 1-1 | Luton Town | |
| Portsmouth | 2-0 | Sheffield United | |
| Queens Park Rangers | 1-2 | Swindon Town | |
| Stoke City | 2-1 | Millwall | |
| Swansea City | 6-1 | Rhyl | |
| Torquay United | 4-3 | Lincoln City | |
| Tottenham Hotspur | 4-1 | Sheffield Wednesday | |
| West Bromwich Albion | 0-0 | Scunthorpe United | |
| Wolverhampton Wndrs | 5-1 | Norwich City | |
| Workington | 0-1 | Brentford | |
| York City | 2-0 | Bolton Wanderers | |
| Tuesday 5th January 1971 | |||
| Barnet | 0-1 | Colchester United | |
| Replay | |||
| Birmingham City | 0-2 | Huddersfield Town | |
| Middlesbrough | 2-1 | Manchester United | |
| Wednesday 6th January 1971 | |||
| Watford | 5-0 | Reading | |
| Yeovil Town | 0-3 | Arsenal | |
| Replay | |||
| Chelsea | 2-0 | Crystal Palace | |
| Monday 11th January 1971 | |||
| Newcastle United | 1-1 | Ipswich Town | |
| Oxford United | 3-0 | Burnley | |
| Rochdale | 2-1 | Coventry City | |
| Rotherham United | 0-0 | Leeds United | |
| Southampton | 3-0 | Bristol City | |
| Southend United | 0-3 | Carlisle United | |
| Sunderland | 0-3 | Leyton Orient | |
| Replay | |||
| Luton Town | 3-4 | Nottingham Forest | |
| Scunthorpe United | 1-3 | West Bromwich Albion | |
| Wednesday 13th January 1971 | |||
| Replay | |||
| Ipswich Town | 2-1 | Newcastle United | |
| Monday 18th January 1971 | |||
| Replay | |||
| Leeds United | 3-2 | Rotherham United | |
